Title : Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.

Pub. Date : 2005 Dec

PMID : 15935620






1 Functional Relationships(s)
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1 Surprisingly, short-term treatment of differentiating C2C12 with geldanamycin increased the phosphorylation of Akt on Ser473, an effect mimicked by treatment of C2C12 cells with okadaic acid or the Hsp90 inhibitor novobiocin. Novobiocin heat shock protein, 2 Mus musculus