Pub. Date : 2005 Dec
PMID : 15933740
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 2 | We report here that exposure to LY294002, a potent PI3K inhibitor, aborts the activation of p53 by several drugs commonly used in cancer chemotherapy. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 3 | Concomitantly, LY294002 attenuates p53-dependent, chemotherapy-induced apoptosis of cancer cells. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |