Title : A phase I pharmacologic and pharmacogenetic trial of sequential 24-hour infusion of irinotecan followed by leucovorin and a 48-hour infusion of fluorouracil in adult patients with solid tumors.

Pub. Date : 2005 Jun 1

PMID : 15930350






1 Functional Relationships(s)
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1 Patients with UDP-glucuronosyltransferase (UGT1A1; TA)6/6 promoter genotype had a lower ratio of free to glucuronide form of SN-38 than in patients with >/=1 (TA)7 allele. Glucuronides UDP glucuronosyltransferase family 1 member A1 Homo sapiens