Pub. Date : 2005 Jun
PMID : 15923615
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MafA is a key regulator of glucose-stimulated insulin secretion. | Glucose | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) | Mus musculus |
| 2 | MafA is a transcription factor that binds to the promoter in the insulin gene and has been postulated to regulate insulin transcription in response to serum glucose levels, but there is no current in vivo evidence to support this hypothesis. | Glucose | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) | Mus musculus |
| 3 | Here we report that MafA mutant mice display intolerance to glucose and develop diabetes mellitus. | Glucose | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) | Mus musculus |
| 4 | These results show that MafA is a key regulator of glucose-stimulated insulin secretion in vivo. | Glucose | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) | Mus musculus |