Title : Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro.

Pub. Date : 1992 Apr 30

PMID : 1591271






8 Functional Relationships(s)
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1 Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro. Iron serotransferrin Oryctolagus cuniculus
2 Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro. Iron serotransferrin Oryctolagus cuniculus
3 The uptake of non-transferrin-bound iron, Fe(II), transferrin-bound iron, Tf-Fe and transferrin was studied in reticulocytes from anaemic rabbits during maturation and then synchronized regeneration in vivo (following injection of actinomycin D) and while maturing during in vitro incubation. Iron serotransferrin Oryctolagus cuniculus
4 The uptake of non-transferrin-bound iron, Fe(II), transferrin-bound iron, Tf-Fe and transferrin was studied in reticulocytes from anaemic rabbits during maturation and then synchronized regeneration in vivo (following injection of actinomycin D) and while maturing during in vitro incubation. Iron serotransferrin Oryctolagus cuniculus
5 The uptake of Fe(II) and Tf-Fe decreased in parallel with each other and with the reticulocyte count and transferrin uptake during maturation in vivo and in vitro. Iron serotransferrin Oryctolagus cuniculus
6 The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased. Iron serotransferrin Oryctolagus cuniculus
7 The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased. Iron serotransferrin Oryctolagus cuniculus
8 The loss of transferrin receptors and the uptake of iron from transferrin during reticulocyte maturation was not associated with a change in the affinity of the receptors for transferrin, in the relative distribution of the receptors between the outer cell membrane and intracellular sites or in the ability of the transferrin molecule to donate two iron atoms to the cell with each intracellular cycle, but the average duration of the cycle increased. Iron serotransferrin Oryctolagus cuniculus