Title : Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe.

Pub. Date : 2005

PMID : 15910012






4 Functional Relationships(s)
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1 Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 DISCUSSION AND CONCLUSION: The contribution of CYP2D6 to MDMA metabolism in humans is not >30%, therefore other CYP isoenzymes may contribute to O-demethylenation of MDMA. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
3 DISCUSSION AND CONCLUSION: The contribution of CYP2D6 to MDMA metabolism in humans is not >30%, therefore other CYP isoenzymes may contribute to O-demethylenation of MDMA. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens
4 Accordingly, the relevance of genetic polymorphism in CYP2D6 activity on MDMA effects and MDMA-induced acute toxicity should be examined as well as the interactions of other CYP2D6 substrates with MDMA, once the enzyme is inhibited. N-Methyl-3,4-methylenedioxyamphetamine cytochrome P450 family 2 subfamily D member 6 Homo sapiens