Pub. Date : 2005 Dec
PMID : 15908181
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Recent evidence indicates cAMP can regulate PKB in some cell types via Epac (Exchange protein directly activated by cAMP). | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Recent evidence indicates cAMP can regulate PKB in some cell types via Epac (Exchange protein directly activated by cAMP). | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Interestingly, the Epac specific cAMP analogue 8-(4-chlorophenylthio)-2"-O-methyl-cAMP potentiated insulin-stimulated PKB phosphorylation in a similar manner as adrenaline did without activating glycogen phosphorylase. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | In conclusion, adrenaline potentiates insulin-stimulated activation of PKB and p70(S6K) via cAMP and Epac in skeletal muscle. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |