Title : Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.

Pub. Date : 2006 Mar 28

PMID : 15893417






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1 We have reported that pretreatment by stomach tube with 8-methoxypsoralen (methoxsalen; 8-MOP), a potent human CYP2A6 inhibitor, strongly suppresses lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice (Cancer Res. 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone cytochrome P450 family 2 subfamily A member 6 Homo sapiens