Title : The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation.

Pub. Date : 2005 May 17

PMID : 15893190






1 Functional Relationships(s)
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1 The effect of SHP-1 was mediated by inhibition of PI3K/Rac1-dependent NAD(P)H-oxidase activation (p < 0.01); SHP-1 AS-ODN augmented tyrosine phosphorylation of the p85 regulatory subunit of PI3K (p < 0.05) and Rac1 activation. Tyrosine Rac family small GTPase 1 Homo sapiens