Title : Attenuation of extracellular acidic pH-induced cyclooxygenase-2 expression by nitric oxide.

Pub. Date : 2005 Apr 30

PMID : 15879708






1 Functional Relationships(s)
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1 When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor). Dactinomycin mitochondrially encoded cytochrome c oxidase II Homo sapiens