Title : p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.

Pub. Date : 2005 May 1

PMID : 15867370






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Herein, we show that p53 translocation to mitochondria precedes its translocation to nucleus in JB6 skin epidermal cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
2 Herein, we show that p53 translocation to mitochondria precedes its translocation to nucleus in JB6 skin epidermal cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
3 Translocation of p53 to mitochondria occurs within 10 minutes after TPA application. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
4 In contrast to the immediate action on mitochondria, p53 transcriptional activity in the nucleus increases at 1 hour following TPA application, accompanied by an increase in the levels of its target gene bax at 15 hours following TPA treatment. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens
5 In contrast to the immediate action on mitochondria, p53 transcriptional activity in the nucleus increases at 1 hour following TPA application, accompanied by an increase in the levels of its target gene bax at 15 hours following TPA treatment. Tetradecanoylphorbol Acetate tumor protein p53 Homo sapiens