Title : Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems.

Pub. Date : 2005 May

PMID : 15867268






3 Functional Relationships(s)
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1 Here, human liver (HepG2) cells were used to model effects of riboflavin concentrations in culture media on folding and secretion of apoB. Riboflavin apolipoprotein B Homo sapiens
2 When cells were cultured in riboflavin-deficient medium, secretion of apoB decreased by >80% compared with controls cultured in physiological medium. Riboflavin apolipoprotein B Homo sapiens
3 Decreased secretion of apoB in riboflavin-deficient cells might interfere with lipid homeostasis in vivo. Riboflavin apolipoprotein B Homo sapiens