Title : Endoplasmic reticulum stress induces the phosphorylation of small heat shock protein, Hsp27.

Pub. Date : 2005 Aug 1

PMID : 15864808






1 Functional Relationships(s)
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1 Treatment targeting the ER with tunicamycin or thapsigargin induced the phosphorylation of Hsp27 but not of alphaB-crystallin in U373 MG cells, increase being observed after 2-10 h and decline at 24 h. Similar phosphorylation of Hsp27 by ER stress was also observed with U251 MG and HeLa but not in COS cells and could be blocked using SB203580, an inhibitor of p38 MAP kinase. SB 203580 heat shock protein family B (small) member 1 Homo sapiens