Pub. Date : 2005 May
PMID : 15857396
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulatory effects of progesterone on inducible nitric oxide synthase expression in vivo and in vitro. | Progesterone | nitric oxide synthase 2, inducible | Mus musculus |
| 2 | Previous studies investigating the therapeutic potential of female sex steroids in stroke and trauma suggest that NO from this source is harmful, since oestradiol and progesterone decreased the level of iNOS expression in vitro and improved neurological outcome. | Progesterone | nitric oxide synthase 2, inducible | Mus musculus |
| 3 | We observed a significant reduction in stroke-induced iNOS transcript in progesterone-treated mice and in cultured macrophages. | Progesterone | nitric oxide synthase 2, inducible | Mus musculus |
| 4 | Astrocytes transiently transfected with iNOS promoter/CAT reporter gene constructs containing the PRE displayed a significant increase in induction of CAT expression after progesterone treatment, and this was diminished in cells transfected with a construct containing a disrupted PRE. | Progesterone | nitric oxide synthase 2, inducible | Mus musculus |
| 5 | These observations suggest the involvement of iNOS in the neuroprotective effects of progesterone. | Progesterone | nitric oxide synthase 2, inducible | Mus musculus |