Pub. Date : 2005 May
PMID : 15855323
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 2 | SCD mRNA expression increased by 48% after rosiglitazone (P < 0.01). | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 3 | SCD and delta5-desaturase but not delta6-desaturase activity indexes were increased after rosiglitazone versus placebo (P < 0.01 and P < 0.05, respectively). | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 4 | In the P467L PPARgamma carrier, SCD and delta5-desaturase activity indexes were exceptionally low but were restored (52- and 15-fold increases, respectively) after rosiglitazone treatment. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 5 | This study shows for the first time that rosiglitazone increases SCD activity indexes and gene expression in humans. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 6 | An increased SCD activity index may reflect increased lipogenesis and might contribute to insulin sensitization by rosiglitazone. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 7 | The restored SCD activity index after rosiglitazone in PPARgamma mutation supports a pivotal role of PPARgamma function in SCD regulation. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |
| 8 | The restored SCD activity index after rosiglitazone in PPARgamma mutation supports a pivotal role of PPARgamma function in SCD regulation. | Rosiglitazone | stearoyl-CoA desaturase | Homo sapiens |