Title : Reduced nNOS expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice.

Pub. Date : 2005 May 20-27

PMID : 15854753






6 Functional Relationships(s)
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1 Reduced nNOS expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice. Nicotine nitric oxide synthase 1, neuronal Mus musculus
2 To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in mu-opioid receptor knockout mice we adopted an immunohistochemical approach. Nicotine nitric oxide synthase 1, neuronal Mus musculus
3 To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in mu-opioid receptor knockout mice we adopted an immunohistochemical approach. Nicotine nitric oxide synthase 1, neuronal Mus musculus
4 Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. Nicotine nitric oxide synthase 1, neuronal Mus musculus
5 However, mu-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. Nicotine nitric oxide synthase 1, neuronal Mus musculus
6 These findings demonstrate that the absence of mu-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment. Nicotine nitric oxide synthase 1, neuronal Mus musculus