Title : [Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells].

Pub. Date : 2005 Mar

PMID : 15854413






4 Functional Relationships(s)
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1 OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens
2 OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens
3 METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens
4 METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens