Pub. Date : 2005 Mar
PMID : 15854413
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | tumor protein p53 | Homo sapiens |
2 | OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | tumor protein p53 | Homo sapiens |
3 | METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | tumor protein p53 | Homo sapiens |
4 | METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | tumor protein p53 | Homo sapiens |