Title : [Production of interleukin-11 in human gingival fibroblasts stimulated with IL-1alpha and tumor necrosis factor-alpha].

Pub. Date : 2004 Nov

PMID : 15854322






3 Functional Relationships(s)
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1 Indomethacin, an inhibitor of prostaglandin synthesis, significantly reduced IL-11 production by HGFs stimulated with IL-1alpha and TNF-alpha individually or in combination. Prostaglandins interleukin 11 Homo sapiens
2 CONCLUSIONS: Production of IL-11 in HGFs stimulated with IL-1alpha and TNF-alpha was transcriptionally upregulated by the endogenous prostaglandin synthesis. Prostaglandins interleukin 11 Homo sapiens
3 Inhibition of prostaglandin might suppress the osteoclastogenesis by IL-11 in inflammatory periodontal diseases. Prostaglandins interleukin 11 Homo sapiens