Title : Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells.

Pub. Date : 2005 May 1

PMID : 15850924






1 Functional Relationships(s)
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1 METHODS AND MATERIALS: The influence of radiation (5 Gy) and hypoxia (1% O2) on reporter-gene expression driven by hypoxia (HRE) and radiation (Egr-1) responsive elements was evaluated in tumor cells grown as monolayers or multicellular spheroids. Oxygen early growth response 1 Homo sapiens