Title : Plasminogen and matrix metalloproteinase activation by enzymatically modified low density lipoproteins in monocytes and smooth muscle cells.

Pub. Date : 2005 Apr

PMID : 15841317






3 Functional Relationships(s)
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1 We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases (MMPs) in monocytes and vascular smooth muscle cells (VSMCs) as well as on MMP activation during cellular interactions. e-ldl matrix metallopeptidase 2 Homo sapiens
2 We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases (MMPs) in monocytes and vascular smooth muscle cells (VSMCs) as well as on MMP activation during cellular interactions. e-ldl matrix metallopeptidase 2 Homo sapiens
3 E-LDL in contrast to n-LDL induced substantial activation of the plasminogen activation system as well as of the MMP system in monocytic cells, as measured by enhanced cell surface expression of the urokinase receptor (uPAR),the extracellular matrix metalloproteinase Inducer (EMMPRIN) and the membrane type-1 MMPs (MT1-MMP,MMP-14), as well as by secretion of active uPA, and of MMP-9. e-ldl matrix metallopeptidase 2 Homo sapiens