Title : The origins of high-affinity enzyme binding to an extrahelical DNA base.

Pub. Date : 2005 Apr 26

PMID : 15835884






1 Functional Relationships(s)
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1 Here we report that UDG kinetically and thermodynamically prefers substrate sites where the uracil is paired with an unnatural adenine analogue that lacks any Watson-Crick hydrogen-bonding groups. Hydrogen uracil DNA glycosylase Homo sapiens