Pub. Date : 2005 Jun 10
PMID : 15817488
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that Fet3p and Ftr1p are post-translationally regulated by iron. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 2 | Incubation of cells in high iron leads to the internalization and degradation of both Fet3p and Ftr1p. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 3 | Yeast strains defective in endocytosis (Deltaend4) show a reduced iron-induced loss of Fet3p-Ftr1p. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 4 | Iron-induced degradation of Fet3p-Ftr1p is significantly reduced in strains containing a deletion of a gene, VTA1, which is involved in multivesicular body (MVB) sorting in yeast. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 5 | Iron-induced internalization and degradation of Fet3p-Ftr1p occurs in a mutant strain of the E3 ubiquitin ligase RSP5 (rsp5-1), suggesting that Rsp5p is not required. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 6 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 7 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 8 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 9 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 10 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |
| 11 | Internalization of Fet3p-Ftr1p is specific for iron and requires both an active Fet3p and Ftr1p, indicating that it is the transport of iron through the iron permease Ftr1p that is responsible for the internalization and degradation of the Fet3p-Ftr1p complex. | Iron | ferroxidase FET3 | Saccharomyces cerevisiae S288C |