Pub. Date : 2005 Jun 24
PMID : 15817479
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. | Ceramides | caspase 2 | Homo sapiens |
| 2 | Stress stimuli, including ceramide and etoposide, caused caspase-2 activation, mitochondrial damage followed by downstream caspase-9 and -3 activation, and cell apoptosis in human lung epithelial cell line A549. | Ceramides | caspase 2 | Homo sapiens |
| 3 | Overexpression of Bcl-2 prevented ceramide- and etoposide-induced caspase-2 activation and mitochondrial apoptosis. | Ceramides | caspase 2 | Homo sapiens |
| 4 | Taken together, ceramide and etoposide induced mitochondria-mediated apoptosis by initiating caspase-2 activation, which was, at least in part, regulated by Bcl-2. | Ceramides | caspase 2 | Homo sapiens |