Pub. Date : 2005 Jul
PMID : 15814533
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we studied the acute effect of GDPs on the expression of tight junction-associated protein, zonula occludens protein 1 (ZO-1), in human peritoneal mesothelial cells (HPMC). | gdps | tight junction protein 1 | Homo sapiens |
| 2 | In the present study, we studied the acute effect of GDPs on the expression of tight junction-associated protein, zonula occludens protein 1 (ZO-1), in human peritoneal mesothelial cells (HPMC). | gdps | tight junction protein 1 | Homo sapiens |
| 3 | The role of the vascular endothelial growth factor (VEGF) induced by GDPs in the expression of ZO-1 was also examined. | gdps | tight junction protein 1 | Homo sapiens |
| 4 | RESULTS: ZO-1 expression in HPMC was downregulated in a time- and dose-dependent manner following culture with subtoxic concentrations of GDPs (FurA, M-Glx and 3,4-DGE). | gdps | tight junction protein 1 | Homo sapiens |
| 5 | Exogenous VEGF downregulated the expression of ZO-1 and neutralizing anti-VEGF antibody reversed the effect of GDPs on ZO-1 expression in HPMC, suggesting the action of GDPs on ZO-1 expression was mediated by VEGF. | gdps | tight junction protein 1 | Homo sapiens |
| 6 | Exogenous VEGF downregulated the expression of ZO-1 and neutralizing anti-VEGF antibody reversed the effect of GDPs on ZO-1 expression in HPMC, suggesting the action of GDPs on ZO-1 expression was mediated by VEGF. | gdps | tight junction protein 1 | Homo sapiens |
| 7 | Exogenous VEGF downregulated the expression of ZO-1 and neutralizing anti-VEGF antibody reversed the effect of GDPs on ZO-1 expression in HPMC, suggesting the action of GDPs on ZO-1 expression was mediated by VEGF. | gdps | tight junction protein 1 | Homo sapiens |
| 8 | Exogenous VEGF downregulated the expression of ZO-1 and neutralizing anti-VEGF antibody reversed the effect of GDPs on ZO-1 expression in HPMC, suggesting the action of GDPs on ZO-1 expression was mediated by VEGF. | gdps | tight junction protein 1 | Homo sapiens |
| 9 | Exogenous VEGF downregulated the expression of ZO-1 and neutralizing anti-VEGF antibody reversed the effect of GDPs on ZO-1 expression in HPMC, suggesting the action of GDPs on ZO-1 expression was mediated by VEGF. | gdps | tight junction protein 1 | Homo sapiens |
| 10 | CONCLUSIONS: We have demonstrated that short-term exposure to GDPs downregulates ZO-1 expression in HPMC through the generation of VEGF. | gdps | tight junction protein 1 | Homo sapiens |