Title : Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

Pub. Date : 2005 Jun 17

PMID : 15809291






1 Functional Relationships(s)
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1 Shear forces, which facilitate GpIbalpha binding (this effect being artificially obtained by ristocetin), can reverse the inhibitory effect of chloride, whose concentration gradient across the cell membrane may represent a simple but efficient strategy to regulate the enzymatic activity of ADAMTS-13. Ristocetin glycoprotein Ib platelet subunit alpha Homo sapiens