Pub. Date : 2005 May
PMID : 15803328
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma. | Bleomycin | transformation related protein 53, pseudogene | Mus musculus |
| 2 | In this study, we examined the induction of apoptosis and the expression of p53, p21 (Waf1/Cip1), and proliferating cell nuclear antigen (PCNA) in the lesional skin following bleomycin exposure in this model. | Bleomycin | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Immunohistochemical examination showed increased expression of p53 and p21 mainly in the infiltrating mononuclear cells at 2 weeks after bleomycin treatment. | Bleomycin | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Reverse transcriptase-polymerase chain reaction analysis showed that the expression of p53 and p21 mRNA was concurrently upregulated at 1-2 weeks after bleomycin treatment. | Bleomycin | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Our findings suggest that apoptotic processes are involved in the pathophysiology of bleomycin-induced scleroderma, which may be mediated, in part, by the upregulation of p53 and p21. | Bleomycin | transformation related protein 53, pseudogene | Mus musculus |