Pub. Date : 2005 May 6
PMID : 15796906
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, the hP2Y6 receptor has been reported to mediate monocyte IL-8 production in response to UDP or lipopolysaccharide (LPS), but the role of hP2Y6 in regulating other pro-inflammatory cytokines or mediators is largely unknown. | Uridine Diphosphate | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | We demonstrate here that UDP specifically induces soluble TNF-alpha and IL-8 production in a promonocytic U937 cell line stably transfected with hP2Y6. | Uridine Diphosphate | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Interestingly, UDP induces the production of IL-8, but not TNF-alpha, in human astrocytoma 1321N1 cell lines stably transfected with hP2Y6. | Uridine Diphosphate | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | From the Taqman analysis, UDP stimulation significantly upregulates the mRNA levels of IL-8, IP-10, and IL-1beta, but not TNF-alpha. | Uridine Diphosphate | C-X-C motif chemokine ligand 8 | Homo sapiens |