Title : Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes.

Pub. Date : 1992 Mar

PMID : 1579548






2 Functional Relationships(s)
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1 Several data indicated that the covalent binding was dependent on P450 enzymes: It was dependent on NADPH, it was induced many times by the P450 IA1 and IA2 upregulators beta-naphthoflavone and polychlorinated biphenyls, and was inhibited by the P450 IA1 and IA2 inhibitor alpha-naphthoflavone. alpha-naphthoflavone protein tyrosine phosphatase, receptor type, N Rattus norvegicus
2 Several data indicated that the covalent binding was dependent on P450 enzymes: It was dependent on NADPH, it was induced many times by the P450 IA1 and IA2 upregulators beta-naphthoflavone and polychlorinated biphenyls, and was inhibited by the P450 IA1 and IA2 inhibitor alpha-naphthoflavone. alpha-naphthoflavone protein tyrosine phosphatase, receptor type, N Rattus norvegicus