Title : Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein.

Pub. Date : 2005 Apr 5

PMID : 15794642






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Affinity chromatography experiments implicate an indirect mechanism of action involving direct binding of EGCG to the AhR chaperone protein, hsp90. epigallocatechin gallate heat shock protein 90 alpha family class A member 1 Homo sapiens
2 These data implicate a model in which EGCG inhibits release of hsp90 from the AhR, stabilizing the complex in an intermediary state associated with XAP2. epigallocatechin gallate heat shock protein 90 alpha family class A member 1 Homo sapiens
3 This is the first time EGCG has been demonstrated to directly bind hsp90 and the first indication that GT may exert its chemopreventive effects through an interaction with the common chaperone hsp90. epigallocatechin gallate heat shock protein 90 alpha family class A member 1 Homo sapiens
4 This is the first time EGCG has been demonstrated to directly bind hsp90 and the first indication that GT may exert its chemopreventive effects through an interaction with the common chaperone hsp90. epigallocatechin gallate heat shock protein 90 alpha family class A member 1 Homo sapiens