Pub. Date : 2005 May 2
PMID : 15790490
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | Recent work in this laboratory demonstrated for the first time that CYP2E1 is the principal enzyme responsible for urethane metabolism. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | The current studies were undertaken to assess the relationships between CYP2E1-mediated metabolism and urethane-induced genotoxicity and cell proliferation as determined by induction of micronucleated erythrocytes (MN) and expression of Ki-67, respectively, using CYP2E1-null and wild-type mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 4 | The current studies were undertaken to assess the relationships between CYP2E1-mediated metabolism and urethane-induced genotoxicity and cell proliferation as determined by induction of micronucleated erythrocytes (MN) and expression of Ki-67, respectively, using CYP2E1-null and wild-type mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 5 | Subsequent comparative metabolism studies demonstrated that total urethane-derived radioactivity in the plasma, liver, and lung was significantly higher in CYP2E1-null versus wild-type mice and un-metabolized urethane constituted greater than 83% of the radioactivity in CYP2E1-null mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 6 | Subsequent comparative metabolism studies demonstrated that total urethane-derived radioactivity in the plasma, liver, and lung was significantly higher in CYP2E1-null versus wild-type mice and un-metabolized urethane constituted greater than 83% of the radioactivity in CYP2E1-null mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 7 | In conclusion, these data demonstrated that CYP2E1-mediated metabolism of urethane, presumably via epoxide formation, is necessary for the induction of genotoxicity, and cell proliferation in the liver and lung of wild-type mice. | Urethane | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |