Pub. Date : 2005 Jun 3
PMID : 15772079
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. | Uridine | uridine phosphorylase 1 | Mus musculus |
| 2 | We report in the present study the critical role of uridine phosphorylase (UPase) in uridine homeostatic regulation and pyrimidine nucleotide metabolism, employing newly developed UPase-/- mice. | Uridine | uridine phosphorylase 1 | Mus musculus |
| 3 | Our data demonstrate that the abrogation of UPase activity led to greater than a 6-fold increase in uridine concentrations in plasma, a 5-6-fold increase in lung and gut, and a 2-3-fold increase in liver and kidney, as compared with wild type mice. | Uridine | uridine phosphorylase 1 | Mus musculus |
| 4 | Urine uridine levels increased 24-fold normal in UPase-/- mice. | Uridine | uridine phosphorylase 1 | Mus musculus |
| 5 | Further, in these UPase-/- mice, abnormal uridine metabolism led to disorders of various nucleotide metabolisms. | Uridine | uridine phosphorylase 1 | Mus musculus |
| 6 | These data indicate that UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity. | Uridine | uridine phosphorylase 1 | Mus musculus |