Title : Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.

Pub. Date : 2005 Mar 24

PMID : 15771425






1 Functional Relationships(s)
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1 The chloro derivative 8b was found to be a highly potent CYP11B2 inhibitor (IC(50) = 4 nM) showing a 5-fold selectivity for CYP11B1 (IC(50) = 20 nM). Sodium Hypochlorite cytochrome P450 family 11 subfamily B member 1 Homo sapiens