Title : Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.

Pub. Date : 2005 Jul

PMID : 15764585






4 Functional Relationships(s)
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1 Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1 group I member 3 Homo sapiens
2 Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1 group I member 3 Homo sapiens
3 Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1 group I member 3 Homo sapiens
4 Secondly, CAR specifically interacted with the first LXXLL motif of ASC-2, and these interactions were stimulated by CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and repressed by CAR inverse agonist androstanol, suggesting that this motif may mediate the interactions of ASC-2 and CAR in vivo. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1 group I member 3 Homo sapiens