Title : Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit.

Pub. Date : 2005 Jul

PMID : 15743887






2 Functional Relationships(s)
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1 Compared with wild-type channels, homomeric and heteromeric channels containing CNGA3-N471S or CNGA3-R563H subunits exhibited an increase in apparent affinity for cGMP and an increase in the relative agonist efficacy of cAMP compared with cGMP. Cyclic AMP cyclic nucleotide gated channel subunit alpha 3 Homo sapiens
2 Compared with wild-type channels, homomeric and heteromeric channels containing CNGA3-N471S or CNGA3-R563H subunits exhibited an increase in apparent affinity for cGMP and an increase in the relative agonist efficacy of cAMP compared with cGMP. Cyclic AMP cyclic nucleotide gated channel subunit alpha 3 Homo sapiens