Title : Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF.

Pub. Date : 2005 Mar 24

PMID : 15735747






1 Functional Relationships(s)
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1 Interestingly, an alpha(13) mutant where a conserved Gly was mutated to a Ser (G205S) retained its ability to bind to p115RhoGEF, induce p115RhoGEF recruitment to the PM, and activate Rho-dependent signaling, even though identical Gly to Ser mutations in other alpha disrupt their interaction with regulator of G-protein signaling (RGS) proteins. Serine paired like homeodomain 2 Homo sapiens