Pub. Date : 2005 Mar
PMID : 15735102
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. | Ellagic Acid | tumor protein p53 | Homo sapiens |
| 2 | We found that quercetin and combinations of quercetin and ellagic acid nonsynergistically increased p53 protein levels. | Ellagic Acid | tumor protein p53 | Homo sapiens |
| 3 | In contrast, ellagic acid potentiated the effects of quercetin for p21(cip1/waf1) protein levels and p53 phosphorylation at serine 15, possibly explaining the synergistic effect observed in apoptosis induction. | Ellagic Acid | tumor protein p53 | Homo sapiens |
| 4 | In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells. | Ellagic Acid | tumor protein p53 | Homo sapiens |