Title : Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma.

Pub. Date : 2005 May

PMID : 15723092






5 Functional Relationships(s)
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1 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate signal transducer and activator of transcription 1 Homo sapiens
2 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate signal transducer and activator of transcription 1 Homo sapiens
3 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate signal transducer and activator of transcription 1 Homo sapiens
4 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate signal transducer and activator of transcription 1 Homo sapiens
5 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. epigallocatechin gallate signal transducer and activator of transcription 1 Homo sapiens