Title : Concentrations of cyclosporin A and FK506 that inhibit IL-2 induction in human T cells do not affect TGF-beta1 biosynthesis, whereas higher doses of cyclosporin A trigger apoptosis and release of preformed TGF-beta1.

Pub. Date : 2005 May

PMID : 15716327






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cyclosporin A (CsA) and FK506 suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFATc), which are central regulators of T cell function. Tacrolimus nuclear factor of activated T cells 1 Homo sapiens