Title : A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.

Pub. Date : 2005 Apr 29

PMID : 15705584






1 Functional Relationships(s)
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1 We also found that although active RhoA, Rac1, and Cdc42 could all mediate Ser-727 and Tyr-705 phosphorylation and nuclear translocation of STAT3, the Rho GTPases were able to induce STAT3 activation independently of the interleukin-6 autocrine pathway, and active RhoA, Rac1, or Cdc42 could not form a stable complex with STAT3 as previously suggested, indicating an unappreciated mechanism of STAT3 activation by the Rho GTPases. Tyrosine ras homolog family member A Mus musculus