Title : Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines.

Pub. Date : 2005 Mar

PMID : 15703815






3 Functional Relationships(s)
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1 Similar reactivation of MGMT gene by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, has also been observed. Polyphenols O-6-methylguanine-DNA methyltransferase Homo sapiens
2 The results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing in the development of ESCC, and this epigenetic event may be prevented or reversed by these polyphenols for the prevention of carcinogenesis. Polyphenols O-6-methylguanine-DNA methyltransferase Homo sapiens
3 The results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing in the development of ESCC, and this epigenetic event may be prevented or reversed by these polyphenols for the prevention of carcinogenesis. Polyphenols O-6-methylguanine-DNA methyltransferase Homo sapiens