Title : Mediators of galactose sensitivity in UDP-galactose 4'-epimerase-impaired mammalian cells.

Pub. Date : 2005 Apr 8

PMID : 15701638






3 Functional Relationships(s)
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1 Unlike its Escherichia coli counterpart, mammalian GALE also interconverts UDP-N-acetylgalactosamine and UDP-N-acetylglucosamine. Uridine Diphosphate N-Acetylglucosamine UDP-galactose-4-epimerase Homo sapiens
2 We found that GALE-null cells accumulated abnormally high levels of Gal-1-P and UDP-Gal and abnormally low levels of UDP-Glc and UDP-GlcNAc in the presence of galactose and that human GALE expression corrected each of these defects. Uridine Diphosphate N-Acetylglucosamine UDP-galactose-4-epimerase Homo sapiens
3 We found that GALE-null cells accumulated abnormally high levels of Gal-1-P and UDP-Gal and abnormally low levels of UDP-Glc and UDP-GlcNAc in the presence of galactose and that human GALE expression corrected each of these defects. Uridine Diphosphate N-Acetylglucosamine UDP-galactose-4-epimerase Homo sapiens