Title : Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes.

Pub. Date : 2005 Feb

PMID : 15681409






2 Functional Relationships(s)
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1 To identify the target of the Nef leucine motif, the native sequence was replaced with either leucine- or tyrosine-based AP-binding sequences from cellular proteins, and the interactions with AP subunits were correlated with function. Tyrosine S100 calcium binding protein B Homo sapiens
2 Tyrosine motifs predictably modulated the interactions between Nef and the mu subunits of AP-1, AP-2, and AP-3; heterologous leucine motifs caused little change in these interactions. Tyrosine S100 calcium binding protein B Homo sapiens