Title : Anti-CD33 monoclonal antibodies enhance the cytotoxic effects of cytosine arabinoside and idarubicin on acute myeloid leukemia cells through similarities in their signaling pathways.

Pub. Date : 2005 Feb

PMID : 15676214






1 Functional Relationships(s)
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Protein Name
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1 Ara-C and IDA induced SHP-1 and SHP-2 protein tyrosine phosphatase (PTPs) phosphorylation and Lyn/SHP-1 complex formation, while VP-16 and Bryostatin did not. Cytarabine LYN proto-oncogene, Src family tyrosine kinase Homo sapiens