Title : Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.

Pub. Date : 2005 Apr

PMID : 15671098






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MCP-1 is stimulated by IL-1beta, TNF-alpha, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones. Metformin C-C motif chemokine ligand 2 Homo sapiens
2 Despite this, MCP-1 may be involved in obesity-related health complications, and the decrease of MCP-1 by metformin and thiazolidinediones suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity. Metformin C-C motif chemokine ligand 2 Homo sapiens