Pub. Date : 2005 Apr
PMID : 15671098
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | MCP-1 is stimulated by IL-1beta, TNF-alpha, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones. | Metformin | C-C motif chemokine ligand 2 | Homo sapiens |
2 | Despite this, MCP-1 may be involved in obesity-related health complications, and the decrease of MCP-1 by metformin and thiazolidinediones suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity. | Metformin | C-C motif chemokine ligand 2 | Homo sapiens |