Pub. Date : 2005 Apr
PMID : 15661808
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells. | Quercetin | androgen receptor | Homo sapiens |
| 2 | Our previous study has shown that quercetin, one of the main polyphenols, can effectively inhibit the expression and function of the AR. | Quercetin | androgen receptor | Homo sapiens |
| 3 | The present study is to address if quercetin may affect Sp1"s action on AR transactivation activity in human prostate adenocarcinoma cell lines, LNCaP and PC-3. | Quercetin | androgen receptor | Homo sapiens |
| 4 | However, the state of interaction of Sp1 with the AR treated by quercetin plus androgen was different from that by androgen treatment or none as demonstrated by coimmunoprecipitation experiments and glutathione S-transferase (GST) pull-down assays. | Quercetin | androgen receptor | Homo sapiens |
| 5 | Moreover, we showed that quercetin caused changes in post-translational modification of AR protein. | Quercetin | androgen receptor | Homo sapiens |
| 6 | The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. | Quercetin | androgen receptor | Homo sapiens |
| 7 | The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. | Quercetin | androgen receptor | Homo sapiens |
| 8 | The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. | Quercetin | androgen receptor | Homo sapiens |