Pub. Date : 2005 Jan 11
PMID : 15649357
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: We show that the binding of activated Cdc42 to the Cool-2 dimer markedly enhances its ability to associate with GDP bound Rac1, resulting in a significant activation of Rac-GEF activity. | Guanosine Diphosphate | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | While the Rac-specific GEF activity of Cool-2 is mediated through the Dbl homology (DH) domain from one monomer and the Pleckstrin homology domain from the other, activated Cdc42 interacts with the DH domain, most likely opposite the DH domain binding site for GDP bound Rac. | Guanosine Diphosphate | AKT serine/threonine kinase 1 | Homo sapiens |