Pub. Date : 2005 Apr
PMID : 15644498
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensitive to inhibition by the coronary vasodilators dilazep and dipyridamole. | Dilazep | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
2 | Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensitive to inhibition by the coronary vasodilators dilazep and dipyridamole. | Dilazep | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
3 | In previous work, we demonstrated that mutation of residues 33 (Met versus Ile) of hENT1 and hENT2 altered sensitivity to dilazep and dipyridamole and that the hENT2 mutant (I33M) displayed a K(m) value for uridine that was lower than that of hENT2 and similar to that of hENT1 (J Biol Chem 277:395-401, 2002). | Dilazep | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |