Title : Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.

Pub. Date : 2005 Jan 31

PMID : 15639337






2 Functional Relationships(s)
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1 While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos. Tetradecanoylphorbol Acetate FBJ osteosarcoma oncogene Mus musculus
2 While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos. Tetradecanoylphorbol Acetate FBJ osteosarcoma oncogene Mus musculus