Pub. Date : 2005 Jan
PMID : 15635177
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ritonavir (RTV) is well known as an inhibitor of many drugs that are metabolized by cytochrome P450 (CYP) 3A or fluxed via P-glycoprotein (Pgp), although it is also reported that RTV is a potent inducer for them. | Ritonavir | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 2 | Ritonavir (RTV) is well known as an inhibitor of many drugs that are metabolized by cytochrome P450 (CYP) 3A or fluxed via P-glycoprotein (Pgp), although it is also reported that RTV is a potent inducer for them. | Ritonavir | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 3 | Ritonavir (RTV) is well known as an inhibitor of many drugs that are metabolized by cytochrome P450 (CYP) 3A or fluxed via P-glycoprotein (Pgp), although it is also reported that RTV is a potent inducer for them. | Ritonavir | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 4 | In this study, to elucidate these contradictory phenomena, functional changes of CYP3A or Pgp during chronic administration of RTV were examined in rats. | Ritonavir | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 5 | It has been confirmed that RTV is not only a potent inhibitor but also a potent inducer of CYP3A, and that RTV is a potent inducer of intestinal Pgp. | Ritonavir | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |