Title : FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L).

Pub. Date : 2005 May 1

PMID : 15626738






1 Functional Relationships(s)
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1 Overexpression of Bcl-x(L) was identified as the critical mediator of drug resistance and recapitulates the PTK inhibitor and daunorubicin-resistant phenotype in FLT3-ITD cells. Daunorubicin BCL2 like 1 Homo sapiens